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KMID : 0191120100250020257
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Journal of Korean Medical Science
2010 Volume.25 No. 2 p.257 ~ p.264
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Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations
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Kim Jeong-Han
Jung Young-Kul
Joo Moon-Kyung
Kim Ji-Hoon
Yim Hyung-Joon
Park Jong-Jae
Kim Jae-Seon
Bak Young-Tae
Yeon Jong-Eun
Byun Kwan-Soo
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Abstract
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The hepatitis B virus (HBV) polymerase gene has overlapping reading frames with surface genes, which allows to alter the amino acid codon of the surface genes. In adefovir (ADV) treated chronic hepatitis B patients carrying rtA181T/rtA181V mutations, overlap with surface gene mutations such as sW172stop/sL173F has been reported. However, the clinical consequences of such surface mutations have not been determined. The aim of this study was to determine the surface gene sequence in ADV-resistant patients carrying the A181T/V mutation and to describe the clinical significance. Of the 22 patients included in this study, 13 were ADV-resistant with rtA181T/V mutations (polymerase mutation group, Group P) and nine were antiviral treatment-naive (control group, Group C). The Pre-S1 gene mutation, V60A, was detected in 11 patients (Group P=8, Group C=3). A start codon mutation in the Pre-S2 gene was found in five patients (Group P=3, Group C=2). An S gene mutation, sA184V, was found in nine patients, all of whom were in group P. Although sW172stop and sL173F mutations were detected, reduced HBsAg titer was not observed. Further study of these mutations and their clinical implications are needed.
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KEYWORD
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Hepatitis B, Chronic, Adefovir, Hepatitis B Surface Antigens
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